Science

PLL-THERAPEUTICS

The PLL-Therapeutics approach: an overview

Our aims is to answer all the aspects of the medical needs …
Our approach aims to answer the main medical needs to treat ALS. It cover the following steps :

Early diagnostic : goal is to start the treatment as soon as possible
Treatment dosage : goal is to determine the best treatment dosage
Treatment follow-up : goal is to follow-up the patient with the diagnostic test and follow the evolution of the disease

1 | EARLY DIAGNOSTIC
– Early diagnostic kit with seric antibodies

– Based on specific antibodies always present in ALS patients blood serum

2 | TREATMENT Initiated
– Based on the specific antibodies, selection of the most adapted composition

– Dose selection

3 | TREATMENT Follow-up
– Adaptation of treatment dose thanks to companion diagnostic

– Better response and increase life expectancy

– Patient follow-up every 3-6 months

The PLL-Therapeutics approach: diagnostics

Development of an accurate diagnostic solution to detect and follow the disease

Dedicated Kit (ALS)

Confirmation of ALS diagnosis + patient follow-up

SPECIFICS MARKERS LINK TO ALS DISEASE METABOLISM AND DYSBIOSIS

The PLL-Therapeutics approach: PLL-001 therapy

… to define the best combination of compounds …

The PLL-Therapeutic approach is based on the following principle :

Active molecules are linked to Poly-L-Lysine (PLL) which increases their half-life and thereby their systemic availability to exert their activity and/or cellular uptake.
Poly-L-Lysine was selected among other half-life enhancers as it may, by itself, have beneficial properties.

Based on the carrier properties of Poly-L-Lysine, we have developed PLL-001, a multifunctional therapy that has demonstrated a breakthrough potential to treat ALS in preclinical studies. PLL-001 is composed of APIs known to be effective against ALS’ neuro-inflammatory and neurodegenerative pathological pathways and to restore the gastrointestinal barrier impermeability.

Science

PLL-THERAPEUTICS

The PLL-Therapeutics approach: an overview

1 | EARLY DIAGNOSTIC

2 | TREATMENT Initiated

3 | TREATMENT Follow-up

The PLL-Therapeutics approach: diagnostics

The PLL-Therapeutics approach: PLL-001 therapy

The PLL-Therapeutic approach is based on the following principle :

More on PLL-001 therapy targets