14 Mai The role of intestinal permeability
Posted at 13:59h
in pll-therapeutics
The way to transport our molecules is to use a dedicated GMP Grade Poly-L-Lysine (PLL) which :
- will increase the half-life of the active molecules of the composition in the body,
- will target the tissues or cells on which the composition molecules are active.
- will allow the active ingredients to pass the blood-brain barrier and to penetrate into the cells, in particular into the neurons and the motor neurons.
- will increase the stability and bioavailability of the active ingredient.
PLL-Butyric acid
![PLL-Butyric acid PLL-Butyric acid](https://www.pll-therapeutics.com/wp-content/uploads/2021/05/PLL-Butyric-acid.jpg)
PLL conjugates in motoneurons and demonstrated that PLL conjugates are internalized in a chronic Experimental animal model.
Anti-conjugated methionine in motoneurons of the spinal cord (A,B).
Immunoreactivity disappeared in antibody preabsorption (C), antibody elimination (D),
Immunoreactivity was absent in vehicle animals (E) and in animals(F).
![Methionine Methionine](https://www.pll-therapeutics.com/wp-content/uploads/2021/05/methionine.jpg)
The Drug product (DP) is divided in 2 DP :
- DP1 dedicated to restore the function of intestinal permeability with for example the regulation of the mucus membranes in particular thanks to PLL-Acetate, PLL-Butyrate…
- DP2 dedicated to be active in regulation of auto immune with PLL-retinoic for example and cell protector, in particular thanks of PLL-pantothenic acid and PLL-CoenzQ10 (protection at the level of mitochondrial chain)
RAT
In-vivo and ex-vivo permeability analysis in rats
After 3 days of DP1 on DSS ( Dextran Sulphate Sodium) 2% rats the gut permeability came back to normal (as on witness) and their behaviour became normal and the inflammation disappear.
![rats rats](https://www.pll-therapeutics.com/wp-content/uploads/2021/05/rats.jpg)
MICE
On Going trial with SOD1 mice with our DP1+DP2
First results after 15 weeks on Rotarod
![mice](https://www.pll-therapeutics.com/wp-content/uploads/2021/05/mice.jpg)